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Recent Publications

  • Moehle, M.S., Luduena, R.F., Haroutunian, V., Meador-Woodruff, J.H., and McCullumsmith, R.E. Regional Differences in Expression of β-Tubulin Isoforms in Schizophrenia. Schizophrenia Research, in press, 2011.
  • Shan, D., Haroutunian, V., Meador-Woodruff, J.H., and McCullumsmith, R.E. Expression of ENT1 Protein in Elderly Patients with Schizophrenia. NeuroReport, in press, 2011.
  • Besing, R.C., Hablitz, L.M., Paul, J.R., Johnson, R.L., Prosser, R.A., and Gamble, K.L. NPY-Induced Phase Shifts of PER2::LUC Rhythms Are Mediated by Long-Term Suppression of Neuronal Excitability in a Phase-Specific Manner. Chronobiology International, in press, 2011.
  • Rubio, M.D., Drummond, J.B., and Meador-Woodruff, J.H. Glutamate Receptor Abnormalities in Schizophrenia: Implications for Innovative Treatments. Biomolecules and Therapeutics, in press, 2011.
  • McCollum, L.A., Roche, J.K., and Roberts, R.C. Immunohistochemical Localization of Enkephalin in the Human Striatum: A Postmortem Ultrastructural Study. Synapse, Published Online Oct 27, 2011. PMID: 22034050 [PubMed]
  • Fargason, R.E., Gamble, K.L., Avis, K.T., Besing, R.C., Jackson, C., Cates, M., and May, R.S. Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD). Psychopharm Bull, in press, 2011.
  • Durgan, D.J., Pat, B.M., Laczy, B., Bradley, J.A., Tsai, J., Grenett, M.H., Ratcliffe,W.F., Brewer, R.A., Nagendran, J., Villegas-Montoya, C., Zou, C., Johnson, R.L., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Chatham, J.C., and Young, M.E. O-GlcNAcylation: A Novel Post-Translational Modification Linking Myocardial Metabolism and the Cardiomyocyte Circadian Clock. Journal of Biol Chem, E-pub ahead of print, Nov 8, 2011. PMID: 22069332 [PubMed]
  • Polter, A.M. and Li, X. Glycogen Synthase Kinase-3 is an intermediate modulator of serotonin neurotransmission. Frontiers in Molecular Neuroscience, in press, 2011.
  • Zhou, W., Chen, L., Yang, S., Li, F., and Li, X. Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice. Biological Psychiatry, in press, 2011.
  • Polter, A.M., Yang, S., Jope, R.S. and Li, X. Functional Significance of Glycogen Synthase Kinase-3 Regulation by Serotonin. Cell Signal, E-pub ahead of print, Sept. 17, 2011. [PubMed]
  • Li, X., Frye, M.A., and Shelton, R.C. Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology, E-pub ahead of print, Sept 7, 2011. PMID: 21900884 [PubMed]
  • Chen L, Zhou W, Chen P, Gaisina I, Yang S, and Li X. Glycogen synthase kinase-3beta is a functional modulator of serotonin 1B receptors. Mol Pharmacol, 79:974-986, 2011. PMID: 21372171 [PubMed]
  • Sodhi MS, Simmons M, McCullumsmith RE, Haroutunian V, and Meador-Woodruff JH: Glutamatergic Gene Expression is Specifically Reduced in Thalamocortical Projecting Relay Neurons in Schizophrenia. Biological Psychiatry. 70: 646-654, 2011. [PubMed]
  • Somerville SM, Conley RR, Roberts RC. Striatal mitochondria in subjects with chronic undifferentiated versus chronic paranoid schizophrenia. Synapse 2011 Sep 9. doi: 10.1002/syn.20981. [Epub ahead of print] [PubMed]
  • Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, Conley RR, Dwivedi Y. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res. 2011 Sept 7. [Epub ahead of print] PMID 21906753 [PubMed]
  • Funk AJ, McCullumsmith RE, Haroutunian V, and Meador-Woodruff JH: Abnormal Activity of the MAPK and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia. Neuropsychopharmacology. In press.
  • Rice MW, Roberts RC, Melendez-Ferro M*and Perez-Costas E* (2011) Neurochemical characterization of the tree shrew dorsal striatum. Frontiers in Neuroanatomy 5:53. doi: 10.3389/fnana.2011.00053
  • Kerman IA, Clinton SM, Simpson DN, Bedrosian TA, Bernard R, Akil H, Watson SJ. Inborn Differences in Environmental Reactivity Predict Divergent Diurnal Behavioral, Endocrine, and Gene Expression Rhythms. Psychoneuroendocrinology, In Press.
  • Sunny R. Slone, Mathieu Lesort, and Talene A. Yacoubian. 14-3-3theta Protects Against Neurotoxicity in a Cellular Parkinson’s Disease Model Through Inhibition of the Apoptotic Factor Bax. PLoS ONE (in Press).
  • Yates, BJ., Kerman, IA., Jian, BJ., Wilson, TD. The vestibulo-autonomic system. In Textbook of Vertigo and Imbalance (Oxford Clinical Neurology Textbook), Ed: Bronstein, A, Oxford University Press. In. Press.
  • Mines, M.A., Beurel, E., and Jope, R.S.: Regulation of cell survival mechanisms in Alzheimer’s disease by glycogen synthase kinase-3 (GSK3). International Journal of Alzheimer’s Disease (2011) in press
  • Sun, M., Zhou, T., Gillespie, G.Y., and Jope, R.S.: The role of DDX3 in regulating Snail. BBA-Molecular Cell Research 1813:438-447 (2011) [PubMed]
  • Kathy B. Avsar, Luke E. Stoeckel, Mark Bolding, David M. White, Malle Tagamets, Henry H. Holcomb, Adrienne C. Lahti: Aberrant visual circuitry associated with normal spatial match-to-sample accuracy in schizophrenia. Psychiatry Research: Neuroimaging, In Press
  • Beurel, E, Song, L, Jope, RS: Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Molecular Psychiatry (2011). In Press.
  • Beurel, E,Wen-I, Y, Michalek, SM, Harrington, LE, and Jope, RS: Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells. Journal of Immunology 186: 1391-1398 (2011). [PubMed]
  • Sodhi MS, Simmons M, McCullumsmith RE, Haroutunian V, and Meador-Woodruff, JH: Glutamatergic Gene Expression is Specifically Reduced in Thalamocortical Projecting Relay Neurons in Schizophrenia. Biological Psychiatry. In Press.
  • Flagel Shelly B, Clark Jeremy J, Robinson Terry E, Mayo Leah, Czuj Alayna, Willuhn Ingo, Akers Christina A, Clinton Sarah M, Phillips Paul EM, and Akil Huda: A selective role for dopamine in stimulus-reward learning. Nature 2011; 469(7328):53-7 [PubMed]
  • Yuskaitis, C. J., Beurel, E., and Jope, R. S. Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X Syndrome. BBA – Molecular Basis of Disease 1802: 1006-1012 (2010) [PubMed]
  • Beurel, E., and Jope, R. S. Glycogen synthase kinase-3 controls inflammatory tolerance in astrocytes. Neuroscience 169: 1063-1070 (2010)
  • Simmons M, Meador-Woodruff JH, Sodhi MS. Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims. Neuroreport. 2010 Oct 27;21(15):993-7. [PubMed]
  • Balon R, Guerra E, Meador-Woodruff JH, Oquendo MA, Salloum IM, Casiano DE, Nemeroff CB. Innovative Approach to Research Training: Research Colloquium for Junior Investigators. Acad Psychiatry. 2011 Spring;35(1):11-14. [PubMed]
  • Ciarleglio, C.M., Axley, J.C., Strauss, B.R., Gamble, K.L. and McMahon, D.G. (2010). “Perinatal photoperiod imprints the circadian clock.” Nat Neurosci, in press. [PubMed]
  • Gamble, K.L.*, Kudo, T., Colwell, C.S., and McMahon, D.G.* (2010). “Gastrin releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons.” J Biol Rhythms, in press. * Co-corresponding authors.
  • Durgan, D.J., Tsai, J., Grenett, M.H., Pat, B.M., Ratcliffe,W.F., Villegas-Montoya, C., Garvey, M.E., Nagendran, J., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Gimble, J.M., and Young, M.E. (2010). “Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice.” Chronobiol Int, in press.
  • Reno C Reyes; Giselle Perry; Mathieu Lesort; Vladimir Parpura. “Immunophilin Deficiency Augments Ca2+-Dependent Glutamate Release from Mouse Cortical Astrocytes” Accepted for publication in Cell Calcium. [PubMed]
  • Li, X., Liu, M., Cai, Z., Wang, G., and Li, X. Regulation of glycogen synthase kinase-3 during bipolar mania treatment. Bipolar Disorders, 12:741-752, 2010.
  • McCullumsmith RE and Meador-Woodruff JH: Novel Approaches to the Study of Postmortem Brain in Psychiatric Illness: Old Limitations and New Challenges. Biological Psychiatry. In press.
  • Kristiansen LV, Bakir B, Haroutunian V, and Meador-Woodruff JH: Expression of the NR2B-NMDA Receptor Trafficking Complex in Prefrontal Cortex From a Group of Elderly Patients With Schizophrenia. Schizophrenia Research. 119: 198-209, 2010.
  • Eppolito AK, Bachus SE, McDonald CG, Meador-Woodruff JH, Smith RF: Late emerging effects of prenatal and early postnatal nicotine exposure on the cholinergic system and anxiety-like behavior. Neurotoxicol Teratol. 2010 May-Jun;32(3):336-45.
  • Sathyasaikumar KV, Stachowski EK, Wonodi I, Roberts RC, Rassoulpour A, McMahon RP, Schwarcz R: (2010) Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophrenia Bulletin, in press.
  • Cristy Tower; Lianwu Fu; Rachel Gill; Mark Prichard; Mathieu Lesort; Elizabeth Sztul: Human Cytomegalovirus UL97 Kinase Prevents the Deposition of Mutant Protein Aggregates in Cellular Models of Huntington’s Disease and Ataxia. Neurobiology of Disease (In Press).
  • Li, X., and Jope, R.S. Is Glycogen Synthase Kinase-3 a Critical Enzyme in Mood Regulation? Neuropsychopharmacology, E-Pub ahead of print July 28, 2010.
  • Simmons M, Meador-Woodruff JH, and Sodhi MS: Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims. NeuroReport. In press.
  • Adrienne L. King, Telisha M. Swain, Dale A. Dickinson, Mathieu J. Lesort, and Shannon M. Bailey: “Chronic ethanol consumption enhances sensitivity to Ca2+-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver”. American Journal of Physiology (In Press)
  • Somerville SM., Conley RR, Roberts RC. Mitochondria in the Striatum of Subjects with Schizophrenia. World Journal of Biological Psychiatry, in press.
  • Mary Y. Heng, Duy K. Duong, *Roger L. Albin, Sara J. Tallaksen-Greene, Jesse M. Hunter, Mathieu J. Lesort, Alex Osmand, Henry L. Paulson, Peter J. Detloff: Early Autophagic Response in a Novel Knock-In Model of Huntington Disease. Human Molecular Genetics (In Press).
  • Perry G, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff P, Albin R and Lesort M.: Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington’s disease. Human Molecular Genetics (in Press).
  • Hammond JC, McCullumsmith RE, Funk AJ, Haroutunian V, and Meador-Woodruff JH: Evidence for Abnormal Forward Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia. Neuropsychopharmacology. In press.
  • Yonghe Li, Wenyan Lu, Taj D. King, Chia-Chen Liu, Gautam N. Bijur and Guojun Bu PLoS One : Dkk1 Stabilizes Wnt Co-receptor LRP6: Implication for Wnt Ligand-induced LRP6 Down-regulation. In-press.
  • Monica E. Calkins, Ph.D., Ping Tepper, Ph.D., Ruben C. Gur, Ph.D., J. Daniel Ragland, Ph.D., Lambertus Klei, Ph.D., Howard W. Wiener, Ph.D., Jan Richard, M.S., Robert M. Savage, Ph.D., Trina B. Allen, M.D., Judith O’Jile, Ph.D., Bernie Devlin, Ph.D., Joseph Kwentus, M.D., Muktar H. Aliyu, M.D., Dr.P.H., L. DiAnne Bradford, Ph.D., Neil Edwards, M.D., Paul D. Lyons, M.D., Ph.D., Vishwajit L. Nimgaonkar, M.D., Ph.D., Alberto B. Santos, M.D., Rodney C.P. Go, Ph.D., and Raquel E. Gur, M.D., Ph.D.: Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS): Evidence for Impairment and Heritability of Neurocognitive Functioning in Families of Schizophrenia Patients. American Journal of Psychiatry. 167: 459-472, 2010.
  • Egleston, B.L., Cropsey, K.L., Lazev, A.B., Heckman, C.J. (2010). A tutorial on principal stratification-based sensitivity analysis: application to smoking cessation studies. Clinical Trials, Apr 27. [Epub ahead of print] PMID: 20423924.
  • Breland, A., Koch, J.R., Shawver, M., Cropsey, K.L. (2010). Assessing the Utility of Consumer Surveys for Improving the Quality of Behavioral Healthcare Service. Journal of Behavioral Health Services & Research. [Epub ahead of print] PMID: 20333475.
  • Cropsey, K.L., Hale, G.J., Jackson, D.O., Villalobos, G.C., Stitzer, M.L. (2010). Psychiatric and substance abuse characteristics of smoking and non-smoking female prisoners. Journal of Behavioral Analysis-Offender and Victim Treatment and Prevention, 2, 104-113.
  • Cropsey, K.L., Matthews, C.A., Campbell, S., Ivey, S., Adawadkar, S. (2010). Long-term, reversible contraception use among high-risk women treated in a university-based gynecology clinic: comparison between IUD and Depo Provera. Journal of Women’s Health, 2, 349-353.
  • Keri A. Barksdale, Emma Perez-Costas, Johanna C. Gandy, Miguel Melendez-Ferro, Rosalinda C. Roberts*, and Gautam N. Bijur* (*co-corresponding authors) Itochondrial Viability in Mouse and Human Postmortem Brain. FASEB Journal (in press)
  • Elizabeth Lucas, Sean Markwardt, Swati Gupta, James Meador-Woodruff, Jiandie Lin, Linda Overstreet-Wadiche, and Rita Cowell: Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1alpha. Journal of Neuroscience, in press.
  • Meredith A. Reid, Luke E. Stoeckel, David M. White, Kathy B. Avsar, Mark S. Bolding, N. Shastry Akella, Robert C. Knowlton, Jan A. den Hollander, and Adrienne C. Lahti: Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia. In Press, Biological Psychiatry
  • Filiano, A.J., Tucholski, J., Dolan, P.J., Gozde, C., Johnson, G.V.W.: Transglutaminase 2 protects against ischemia stroke. Neurobiology of Disease, in press.
  • Axtell, R. C., de Jong, B. A., Boniface, K., van der Voort,, L. F., Bhat, R., De Sarno, P, Naves, R., Han, M., Zhong, F., Castellanos, J. G., Mair, R., Christakos, T., Kolkowitz, I., Katz, L., Killestein, J., Polman, C. H., de Waal Malefyt, R., Steinman, L and Raman, C. 2010. T-helper types 1 and 17 determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis. Nat. Medicine 16:406:412.
  • Polter AM, Li X., 5-HT1A Receptor-Regulated Signal Transduction Pathways in Brain. Cell Signal. 2010 Apr 1. [Epub ahead of print]
  • Mines, M. A., Yuskaitis, C. J., King, M. K., Beurel, E., and Jope, R. S.: (2010) GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of Fragile X syndrome and autism. PLoS One 5 (3): e9706
  • Beurel, E., Michalek, S. M., and Jope, R. S.: Innate and adaptive immune responses regulated by glycogen synthase kinase-3. Trends in Immunology 31:24-31 (2010)
  • Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., and Jope, R. S.: Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X Syndrome. Biochemical Pharmacology 79: 632-646 (2010)
  • Balon R, Guerra E, Meador-Woodruff JH, Oquendo MA, Salloum IM, Casiano DE, and Nemeroff CB: Innovative Approach to Research Training: Research Colloquium for Junior Investigators. Academic Psychiatry. In press.
  • Kristiansen LV, Patel SA, Haroutunian V, Meador-Woodruff JH. Expression of the NR2B-NMDA receptor subunit and its Tbr-1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia. Synapse. 2010 Feb 19;64(7):495-502.
  • Kristiansen LV, Bakir B, Haroutunian V, and Meador-Woodruff JH: Expression of the NR2B-NMDA Receptor Trafficking Complex in Prefrontal Cortex From a Group of Elderly Patients With Schizophrenia. Schizophrenia Research. In press.
  • Abigail Polter, Eleonore Beurel, Sufen Yang, Rakesha Garner, Ling Song, Courtney A. Miller, J. David Sweatt, Lori McMahon, Alfred A. Bartolucci, *§Xiaohua Li, and *§Richard S. Jope. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. *§Corresponding authors and Equal contribution. Neuropsychopharmacology. In press.
  • Emma Perez-Costas, Miguel Melendez-Ferro, Rosalinda C Roberts. Basal ganglia pathology in schizophrenia: Dopamine connections and anomalies. Journal of Neurochemistry 2010 [Epub ahead of print] PMID: 20089137
  • Janusz Tucholski. TG2 protects neuroblastoma cells against DNA-damage induced stress, suppresses p53 activation. Amino Acids. (In press)
  • Emma Perez-Costas, Johanna C. Gandy, Miguel Melendez-Ferro, Rosalinda C. Roberts, and Gautam N. Bijur* Light and electron microscopy study of glycogen synthase kinase-3β in the mouse brain. PLoS ONE. (In press)
  • Axtell, R. C., de Jong, B. A., Boniface, K., van der Voort,, L. F., Bhat, R., De Sarno, P, Naves, R., Han, M., Zhong, F., Castellanos, J. G., Mair, R., Christakos, T., Kolkowitz, I., Katz, L., Killestein, J., Polman, C. H., Malefyt, R. de W., Steinman, L and Raman, C. TH1 and TH17 Pathways Determine Opposite Results of IFN-β treatment of Experimental Autoimmune Encephalomyelitis and Relapsing Remitting Multiple Sclerosis. Nature Medicine (in press).
  • Madan A, White-Williams C, Borckardt JJ, Rayburn BK, Bush BA, Thurstin AH. “Assessing Historical Compliance with Medical Recommendations among Transplant Candidates: Preliminary Findings.” Progress in Transplantation (In press)
  • Schwarz LR, Thurstin AH, and Levine LA. “Grand Rounds: A Single Case Report of Moyamoya Disease Presenting in a Psychiatric Setting”. Applied Neuropsychology (In press)
  • Cropsey, K.L., McClure, L.A., Jackson, D.O., Villalobos, G.C., Weaver, M.F., Stitzer, M.L. The impact of quitting smoking on weight in female prisoners participating in a smoking cessation intervention. American Journal of Public Health. (In press)
  • Cropsey, K.L., Jones, S. Jackson, D.O., Hale, G.J. Smoking characteristics of community corrections clients. Nicotine and Tobacco Research. (In press).
  • Cropsey, K.L., Matthews, C.A., Campbell, S., Ivey, S., Adawadkar, S. Long-term, reversible contraception use among high-risk women treated in a university-based gynecology clinic: comparison between IUD and Depo Provera. Journal of Women’s Health.